Prognostic and diagnostic roles of serum ferritin level in cancer

The ferritin level, a protein responsible for iron metabolism and storage, is sensitive indicator of overload in various pathological conditions. In leukemia, levels increase with disease stages can predict survival after transplantation. Leukemia-induced dysregulation the ferroportin-hepcidin regulatory axis results intracellular accumulation, activation reactive oxygen species (ROS)-related signaling pathway, inhibition hematopoiesis, leading to anemia increased dependence on red blood cell transfusions, thereby disrupting physiological cycle. Additionally, rise other types cancer, indicating its potential as target both diagnosis treatment. Therefore, understanding role leukemia diseases crucial developing effective treatment strategies enhance patient outcomes.